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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AURKA
All Species:
12.12
Human Site:
S66
Identified Species:
17.78
UniProt:
O14965
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14965
NP_003591.2
403
45809
S66
L
Q
A
Q
K
L
V
S
S
H
K
P
V
Q
N
Chimpanzee
Pan troglodytes
XP_525364
403
45791
S66
L
Q
A
Q
K
L
V
S
S
H
K
P
V
Q
N
Rhesus Macaque
Macaca mulatta
XP_001098364
471
52859
S133
L
E
A
H
Q
P
E
S
D
P
Q
P
L
S
G
Dog
Lupus familis
XP_853397
405
45606
S67
P
Q
T
Q
K
L
V
S
S
H
K
P
A
Q
N
Cat
Felis silvestris
Mouse
Mus musculus
P97477
395
44754
Q66
A
Q
K
L
G
A
G
Q
K
P
A
P
K
Q
L
Rat
Rattus norvegicus
P59241
397
44856
Q66
A
Q
K
P
V
A
G
Q
K
P
V
L
K
Q
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521399
303
34973
Chicken
Gallus gallus
XP_425725
409
46456
L70
V
Q
S
Q
K
S
S
L
S
N
Q
K
L
S
N
Frog
Xenopus laevis
Q91819
408
46443
L68
M
Q
A
Q
K
P
V
L
S
N
Q
K
P
T
A
Zebra Danio
Brachydanio rerio
Q6NW76
320
36928
S16
P
R
V
Q
Q
T
P
S
A
G
V
G
P
L
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKN7
329
38282
E24
L
L
A
K
V
P
E
E
H
Q
E
P
I
K
N
Honey Bee
Apis mellifera
XP_395732
327
37711
P23
S
K
T
T
E
R
I
P
N
A
T
D
D
E
K
Nematode Worm
Caenorhab. elegans
O01427
305
34731
Sea Urchin
Strong. purpuratus
XP_001181990
278
32048
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q683C9
282
32738
Baker's Yeast
Sacchar. cerevisiae
P38991
367
42927
N63
L
N
R
L
P
V
N
N
K
K
F
L
D
M
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
100
47.7
89.8
N.A.
82.6
83.6
N.A.
65.5
73.1
65.9
53.3
N.A.
38.4
53
46.6
50.6
Protein Similarity:
100
100
62.2
93
N.A.
86.8
87.3
N.A.
70.2
82.8
77.2
65.7
N.A.
57.8
67
56.3
60
P-Site Identity:
100
100
26.6
80
N.A.
20
13.3
N.A.
0
33.3
40
13.3
N.A.
26.6
0
0
0
P-Site Similarity:
100
100
53.3
80
N.A.
20
13.3
N.A.
0
66.6
60
33.3
N.A.
53.3
33.3
0
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.4
38.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.3
57.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
13
0
32
0
0
13
0
0
7
7
7
0
7
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
7
0
0
7
13
0
0
% D
% Glu:
0
7
0
0
7
0
13
7
0
0
7
0
0
7
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% F
% Gly:
0
0
0
0
7
0
13
0
0
7
0
7
0
0
7
% G
% His:
0
0
0
7
0
0
0
0
7
19
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
7
0
0
0
0
0
7
0
0
% I
% Lys:
0
7
13
7
32
0
0
0
19
7
19
13
13
7
7
% K
% Leu:
32
7
0
13
0
19
0
13
0
0
0
13
13
7
13
% L
% Met:
7
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% M
% Asn:
0
7
0
0
0
0
7
7
7
13
0
0
0
0
32
% N
% Pro:
13
0
0
7
7
19
7
7
0
19
0
38
13
0
0
% P
% Gln:
0
44
0
38
13
0
0
13
0
7
19
0
0
32
0
% Q
% Arg:
0
7
7
0
0
7
0
0
0
0
0
0
0
0
7
% R
% Ser:
7
0
7
0
0
7
7
32
32
0
0
0
0
13
0
% S
% Thr:
0
0
13
7
0
7
0
0
0
0
7
0
0
7
0
% T
% Val:
7
0
7
0
13
7
25
0
0
0
13
0
13
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _